The formation of carbon-carbon bonds is of great importance for the development of pharmaceuticals and other biologically active molecules, and functional materials. In contrast to traditional cross-coupling chemistry, C–H activation requires no prefunctionalization of the substrates. However, the applicability of C–H activation chemistry has been limited mainly by the inert nature of the carbon-hydrogen bond. Our group has developed continuous-flow strategies to boost the reactivity of C–H activation chemistry.
- A Modular Flow Design for the meta-Selective C−H Arylation of Anilines. Gemoets, H. P. L.; Laudadio, G.; Verstraete, K.; Hessel, V.; Noël, T., Angew. Chem., Int. Ed. 2017, 56 (25), 7161-7165.
- Mild and selective base-free C–H arylation of heteroarenes: experiment and computation. Gemoets, H. P. L.; Kalvet, I.; Nyuchev, A.; Erdmann, N.; Hessel, H.; Schoenebeck, F.; Noël, T., Chem. Sci. 2017, 8, 1046-1055.
- Palladium-catalyzed aerobic oxidative coupling of o-xylene in flow: a safe and scalable protocol for cross-dehydrogenative coupling. Erdmann, N.; Su, Y.; Bosmans, B.; Hessel, V.; Noel, T., OPR&D 2016, 20 (2), 568-573.
- Aerobic C–H olefination of indoles via a cross-dehydrogenative coupling in continuous flow. Gemoets, H. P. L.; Hessel, V.; Noël, T., Org. Lett. 2014, 16, 5800-5803.