Visible light photoredox catalysis enables challenging organic transformations to be carried out under mild reaction conditions. However, the applicability of photoredox catalysis has been hampered due to the limited scalability. Our group has been engaged in developing novel photocatalytic methods to enable C–CF3, S–CF3, C–S and S–S bond forming reactions. A substantial acceleration is observed when this chemistry is translated to continuous-flow: from hours/days in batch to seconds/minutes in flow.
- Visible Light-Mediated Selective Arylation of Cysteine in Batch and Flow. Bottecchia, C.; Rubens, M.; Gunnoo, S.; Hessel, V.; Madder, A. and Noël, T. Angewandte Chemie International Edition 2017, 56 (41), 12701-12707
- Practical Photocatalytic Trifluoromethylation and Hydrotrifluoromethylation of Styrenes in Batch and Flow Straathof, N. J. W.; Cramer, S. E.; Hessel, V. and Noël, T. Angewandte Chemie International Edition 2016, 55 (50), 15549-15553
- Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment. Cambié, D.; Bottecchia, C.; Straathof, N. J. W.; Hessel, V. and Noël, T. Chemical Reviews 2016, 116 (17), 10276-10341
- Accelerated Gas-liquid Visible Light Photoredox Catalysis with Continuous-Flow Photochemical Microreactors. Straathof, N. J. W.; Su, Y.; Hessel, V. and Noël, T. Nature Protocols 2016, 11, 10-21.
- A Mild, One-pot Stadler-Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous-flow. Wang, X.; Cuny, G. D. and Noël, T. Angewandte Chemie International Edition 2013, 52, 7860-7864.