Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Our aim is to use flow chemistry (i) to improve the reaction efficiency, (ii) to enable gas-liquid reactions, (iii) to carry out hazardous chemistry (e.g. explosive regime) and (iv) to streamline multistep reaction sequences in an uninterrupted and automated fashion which requires no intermediate handling.
- Intermolecular Transition-Metal-Catalyzed C–C Coupling Reactions in Continuous Flow. Bottecchia, C.; Noël, T. Science of Synthesis: Flow Chemistry in Organic Synthesis, Eds. T.F. Jamison and G. Koch, 2018, 313, 313-346. (DOI 10.1055/sos-SD-228-00200)
- A leaf-inspired luminescent solar concentrator for energy-efficient continuous-flow photochemistry. Cambié, D.; Zhao, F.; Hessel, V.; Debije, M. G.; Noël, T. Angew. Chem. Int. Ed. 2017, 56 (4), 1050-1054.
- Continuous-flow multi-step synthesis of Cinnarizine, Cyclizine and a Buclizine derivative from bulk alcohols. Borukhova, S.; Noël, T.; Hessel, V. ChemSusChem, 2016, 9, 67-74.
- Liquid phase oxidation chemistry in continuous-flow. Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel, V.; Luque, R.; Noël, T., Chem. Soc. Rev. 2016, 45, 83-117.
- Leaching-Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions. Schröder, F.; Erdmann, N.; Noël, T.; Luque, R.; Van der Eycken, E. V. Adv. Synth. Catal. 2015, 357, 3141-3147.
- Separation/Recycling Methods of Homogeneous Transition Metal Catalysts in Continuous Flow. Vural-Gursel, I.; Noël, T.; Wang, Q.; Hessel, V., Green Chem. 2015, 17, 2012-2026.
- Solvent- and catalyst-free Huisgen cycloaddition towards Rufinamide in flow with decision on a greener and less expensive dipolarophile. Borukhova, S.; Noël, T.; Metten, B.; de Vos, E.; Hessel, V., ChemSusChem 2013, 6, 2220-2225.